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Doxycycline


Generic Name: Doxycycline

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Tablets

Doxycycline contains the active ingredient doxycycline, which belongs to a group of antibiotics called the tetracyclines. Doxycycline is an antibiotic that has the ability to inhibit the growth of a wide variety of bacteria and certain other organisms. It works by preventing bacteria from producing proteins that are essential to them. Without these proteins the bacteria cannot grow, replicate and increase in numbers. Doxycycline therefore stops the spread of the infection and the remaining bacteria eventually die.

Doxycycline is indicated to treat:
- Various other infections caindicated by susceptible bacteria and micro-organisms;
- Urinary tract;
- Eye and sexually transmitted infections;
- A wide variety of respiratory;

Doxycycline is also indicated for severe acne, as Doxycycline is active against the bacteria associated with acne, Propionebacterium acnes. This is a common type of bacteria that feeds on sebum produced by the sebaceous glands in the skin. It produces waste products and fatty acids that irritate the sebaceous glands, making them inflamed and causing spots. By controlling bacterial numbers, doxycycline brings the inflammation of the sebaceous glands under control, and the skin is allowed to heal.

Doxycycline is also active against the parasite that causes malaria. Doxycycline is sometimes indicated to treat malaria, and can also be indicated to prevent it when visiting high-risk malarial areas, in particular areas where the malaria parasite is resistant to chloroquine.

Doxycycline is an antibiotic indicated to treat bacterial infections.

Swallow doxycycline tablets whole (not crushed or chewed), with plenty of water, while sitting or standing - this will stop them from sticking in the throat and causing irritation.

The most common side effects are nausea, vomiting and diarrhoea.

Doxycycline stops bacteria from functioning and so stops numbers from increasing.

Antibiotic

Doxycycline is a synthetic (man-made) antibiotic derived from tetracycline. Doxycycline works by interrupting the production of proteins by bacteria. Doxycycline is effective against a wide variety of bacteria, such as:
- Chlamydia psittaci;
- Chlamydia trachomatis;
- Hemophilus influenzae;
- Mycoplasma pneumoniae;
- Neisseria gonorrhoea;
- Streptococcus pneumoniae;

Doxycycline is a broad-spectrum tetracycline antibiotic indicated against a wide variety of bacterial infections, including:
- Urinary tract infections;;
- Trachoma (chronic infections of the eye);;
- Some gonococcal infections in adults;
- Rocky Mountain spotted fever and other fevers caindicated by ticks fleas and lice;;

Doxycycline is an approved treatment for inhalational anthrax. Doxycycline is also indicated with other medications to treat severe acne and amoebic dysentery (diarrhea caindicated by severe parasitic infection of the intestines).

Doxycycline may also be taken for the prevention of malaria on foreign trips of less than 4 months' duration.

Occasionally doctors prescribe doxycycline to treat early Lyme disease and to prevent "traveler's diarrhea." These are not yet officially approved uses for this drug.

Generally, children under 8 years old and women in the last half of pregnancy should not take Doxycycline. Doxycycline may cause developing teeth to become permanently discolored. (However, children under 8 may be given this drug for inhalational anthrax.)

Indications

Acne vulgaris
Bubonic plague
Chlamydia
Cholera
Chronic bronchitis
Death and decay of tissue in a infected wound due to gas production by the infecting bacteria (gas gangrene)
Disease caindicated by infection with Leptospira bacteria (Weil's Disease/leptospirosis)
Disease of rodents and rabbits that can be transmitted to humans (tularaemia)
Eye infections
Gonorrhoea
Infection caindicated by Brucella bacteria (brucellosis)
Infection of the lungs and airways (chest or lower respiratory tract infection)
Infections caindicated by Rickettsiae micro-organisms transmitted by lice, fleas, ticks and mites
Infections of the urinary tract
Infectious disease of parrots and man (parrot fever/psittacosis)
Infectious disease of rodents that can be transmitted to humans (melioidosis)
Inflammation of the sinuses due to infection (sinusitis)
Lesions in the groin and genitalia caindicated by a sexually transmitted bacteria (granuloma inguinale)
Louse and tick-bourne relapsing fever
Pneumonia
Prevention of an infectious disease called Scrub typhus
Prevention of infection with Leptospira bacteria (leptospirosis)
Prevention of malaria
Prevention of traveller's diarrhoea (enterotoxigenic E coli)
Protozoal infection of the intestine (amoebiasis)
Sexually transmitted infection that causes genital ulcers (chancroid)
Syphilis
Tetanus
Treatment of malaria caindicated by chloroquine-resistant Plasmodium falciparum

Doxycycline is indicated for many different types of infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. Doxycycline is indicated for the treatment of nongonococcal urethritis (due to Ureaplasma), Rocky mountain spotted fever, typhus, chancroid, cholera, brucellosis, anthrax, syphilis, and acne.

Side effects


Abdominal pain;
Abnormal reaction of the skin to light usually a rash (photosensitivity);
Angioedema (chest pain swelling of face around lips tongue and throat arms and legs difficulty swallowing);
Blood disorders;
Bulging foreheads in infants;
Diarrhea or loose stools;
Diarrhea;
Diarrhoea;
Difficulty or pain when swallowing (dysphagia);
Difficulty swallowing;
Discolored teeth in infants and children (more common during long-term use of tetracycline);
Disturbances of liver function;
Feeling or being sick;
Heartburn;
Hypersensitivity reactions such as swelling of the lips throat and tongue (angioedema) itchy blistering rash or anaphylactic shock;
Inflammation of the food pipe (oesophagitis);
Inflammation of the intestines (enterocolitis);
Inflammation of the tongue;
Loss of appetite;
Mild increase in pressure within the skull (benign intracranial hypertension);
Nausea and vomiting;
Nausea;
Noises in the ear;
Rash;
Rectal or genital itching;
Severe allergic reaction (hives itching and swelling);
Skin rashes;
Skin sensitivity to light;
Sore or painful tongue or mouth;
Soreness and itching of the rectal or genital area;
Vomiting;

Forms

Capsules: 40 milligrams,
Capsules: 50 milligrams,
Capsules: 75 milligrams,
Capsules: 100 milligrams.
Tablets: 50 milligrams,
Tablets: 75 milligrams,
Tablets: 100 milligrams,
Tablets: 150 milligrams.
Suspension: 25 milligrams/teaspoon.
Syrup: 50 milligrams/teaspoon.
Powder for injection: 42.5 milligrams,
Powder for injection: 100 milligrams,
Powder for injection: 200 milligrams.

Dosages

ADULTS

The usual dose of oral doxycycline is 200 milligrams on the first day of treatment (100 milligrams every 12 hours) followed by a maintenance dose of 100 milligrams per day. The maintenance dose may be taken as a single dose or as 50 milligrams every 12 hours.

Your doctor may prescribe 100 milligrams every 12 hours for severe infections such as chronic urinary tract infection.

For Uncomplicated Gonorrhea (Except Anorectal Infections in Men)

The usual dose is 100 milligrams by mouth, twice a day for 7 days. An alternate, single-day treatment is 300 milligrams, followed in 1 hour by a second 300-milligram dose.

For Primary and Secondary Syphilis

The usual dose is 200 milligrams a day, divided into smaller, equal doses for 14 days.

For Inhalational Anthrax

To prevent or combat infection after exposure, the usual dose is 100 milligrams taken by mouth twice a day for 60 days. Treatment can be started intravenously, but should be switched to oral doses as soon as possible.

For Prevention of Malaria

The usual dose is 100 milligrams a day. Treatment should begin 1 to 2 days before travel to the area where malaria is found, then continue daily during travel in the area and 4 weeks after leaving.

CHILDREN

For children above 8 years of age, the recommended dosage schedule for those weighing 100 pounds or less is 2 milligrams per pound of body weight, divided into 2 doses, on the first day of treatment, followed by 1 milligram per pound of body weight given as a single daily dose or divided into 2 doses on subsequent days.

For more severe infections, up to 2 milligrams per pound of body weight may be used.

For inhalational anthrax in children weighing less than 100 pounds, the usual dose is 1 milligram per pound of body weight twice daily for 60 days.

For prevention of malaria, the recommended dose is 2 milligrams per 2.2 pounds of body weight up to 100 milligrams.

For children over 100 pounds, the usual adult dose should be used.

The absorption of doxycycline is not markedly affected by food, and therefore, Doxycycline can be taken with meals. For most infections, doxycycline is taken once or twice daily for 7 to 14 days. For adult infections, the usual dose of oral doxycycline is 200 milligrams on the first day of treatment (100 milligrams every 12 hours) followed by a dose of 100 milligrams/day as a single dose or 50 milligrams twice daily.

Dosages

In some countries Doxycycline may also be known as:
- Aliudox;
- Asolmicina;
- Atridox;
- Bassado;
- Biodoxi;
- Bronmycin;
- Ciclidoxan;
- Ciclisan;
- Clordox;
- Deoxymykoin;
- Docdoxycy;
- Doksin;
- Doryx;
- Dotur;
- Doxal;
- Doxibiot;
- Doxicip;
- Doxiclival;
- Doxilina;
- Doxithal;
- Doxsig;
- Doxy;
- Doxybene;
- Doxyderm;
- Doxyderma;
- Doxydyn;
- Doxyhexal;
- Doxy-HP;
- Doxylan;
- Doxylets;
- Doxylin;
- Doxy-N-Tablinen;
- Doxypal-DR;
- Doxypalu;
- Doxyratio M;
- Doxystad;
- Doxy-Wolff;
- DuraDox;
- Frakas;
- Geeox;
- Granudoxy;
- Granudoxy;
- Harvellin;
- Helvedoclyn;
- Huma-Doxylin;
- Impalamycin;
- Medomycin;
- Monodoks;
- Neo Doxicilin;
- Otosal;
- Pluridoxina;
- Poli-Cycline;
- Protectina;
- Relyomycin;
- Retens;
- Rudocycline;
- Servidoxyne;
- Siadocin;
- Sigadoxin;
- Smilitene;
- Spanor;
- Supracyclin;
- Tasmacyclin Akne;
- Tolexine;
- Tremesal;
- Uni Doxiciclin;
- Verboril;
- Vibramicina C;
- Vibramicina;
- Vibra-Tabs;
- Vibraveineuse;
- Vibravenos;
- Vivradoxil;
- Wanmycin;
- Zadorine;

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