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Chlorsig is a broad spectrum antibiotic originally isolated from Streptomyces venezuelae. Chlorsig is
primarily bacteriostatic and acts by inhibition of protein synthesis by interfering with the transfer of activated amino acids
from soluble RNA to ribosomes. Chlorsig is indicted for the treatment of bacterial conjunctivitis and other
superficial ocular infections caused by chloramphenicol-sensitive organisms.
Blood dyscrasias have been reported in association with the use of chloramphenicol. Chloramphenicol is absorbed systemically
from the eye, and toxicity has been reported following chronic exposure. Dose related toxicity following a single ocular
exposure is unlikely. Local irritation with the ophthalmic form may include subjective symptoms of itching or burning.
More serious side effects such as:
- Angioneurotic oedema;
- Vesicular and maculopapular dermatitis;
have been reported in patients sensitive to chloramphenicol and are causes for discontinuing the medication.
Similar sensitivity reactions to other materials in topical preparations also may occur.
In some countries Chlorsig may also be known as:
- Golden Eye;
- Isopto Fenicol;
- Leclor A;
- Neo Fenicol;
- Oftan Akvakol;
- Oftan Chlora;
- Optrex Infected Eyes;
- Posifenicol C;
- Thilocanfol C;
- Uni Fenicol;